Holotomographic Microscope and Micromanipulator System for Assisted Reproductive Technologies

Holotomographic Microscope and Micromanipulator System for Assisted Reproductive Technologies

TÜBİTAK 1501   2022 – 2023   ·   Co-Investigator

The project produced a holotomographic microscope coupled with an integrated micromanipulator for use in assisted reproductive technologies.

The system delivers label-free 3D imaging of living gametes and embryos, supporting clinical decision-making during ICSI, embryo selection, and morphokinetic monitoring while minimising photodamage and contrast-agent exposure. Quantitative phase imaging recovers refractive-index distributions that correlate with cellular composition, providing information not accessible through conventional bright-field microscopy.

The work translates ASIL’s holographic-microscopy and microrobotic-manipulation expertise into a clinically aligned platform for embryology laboratories. The project is funded under TÜBİTAK’s 1501 Industry R&D programme, which supports application-driven research with industrial partners.

Funder: TÜBİTAK 1501 — Industry R&D Projects Support Programme. Project period: 2022–2023.