High-Frequency Optical Tweezing for Detection and Classification of Cancerous Cells

High-Frequency Optical Tweezing for Detection and Classification of Cancerous Cells

BAP — Higher Education   2022 – 2024   ·   Principal Investigator

The project developed a high-frequency optical-tweezing system for the detection and classification of cancerous cells, combining optical micromanipulation with quantitative cellular biomarkers.

Optical tweezing applies precisely controlled trapping forces to individual cells, enabling label-free measurement of mechanical and optical properties relevant to malignancy. Combined with quantitative phase imaging and supervised classification, the system supports research workflows in oncology and label-free single-cell analysis.

The system contributes to ASIL’s expanding toolkit for cancer mechanobiology, complementing ongoing work on cell-stiffness mapping and circulating-tumour-cell analysis. Outcomes are aligned with the lab’s broader programme on translational technologies for early cancer detection and personalised oncology.

Funder: Yıldız Technical University BAP — Research Project. Project period: 2022–2024.