This project aims to measure the mechanical stiffness of biological structures such as cells, micro-tissues, and spheroids in real time using an innovative, non-invasive magneto-holographic system.
The method involves applying controlled magnetic forces to magnetic nanoparticles attached to the cell surface and capturing the resulting mechanical displacement using holographic imaging. This approach enables comparative analysis of various biological structures, providing critical insights into cellular mechanics. By incorporating viscoelastic behavior analysis, the study contributes to understanding cell deformation, mechanical responses, and their role in crucial biological processes, including cancer progression, tissue engineering, and regenerative medicine. The developed technique offers a high-speed alternative to conventional methods, such as Atomic Force Microscopy, improving measurement efficiency by approximately 1000 times. Additionally, it has significant applications in disease modeling, immunotherapy, and drug development by enabling precise, real-time analysis of cellular and micro-tissue stiffness.